semaglutide · daily tablet
Rybelsus dose schedule
US label revised 1/2026 · Checked 31 October 2026
Quick answer
Rybelsus (semaglutide) is taken once a day. The label starts at 3 mg for 30 days, then 7 mg. From day 61, if more blood sugar control is needed, it can go up to 14 mg.
Rybelsus titration schedule
For type 2 diabetes, and other uses on its label.
Days on each dose
- 3 mg Days 1 to 30
- 7 mg Day 31 on
- 14 mg If needed, from day 61
- Starting dose
- A dose the label allows staying on
- Dashed ring: only if the prescriber steps up
| When | Daily dose | From the label |
|---|---|---|
| Days 1 to 30 | 3 mg | Starting dose; the label says it doesn’t lower blood sugar |
| Day 31 on | 7 mg | An ongoing dose |
| If needed, from day 61 | 14 mg | If more blood sugar control is needed |
The label’s ongoing dose is 7 mg once a day, or 14 mg if more blood sugar control is needed.
Good to know
- One tablet each morning on an empty stomach, swallowed whole with up to 4 ounces (120 mL) of plain water. Wait 30 minutes before eating, drinking, or taking other pills. One tablet a day at most.
- Rybelsus and Ozempic tablets are not swapped milligram for milligram: the label pairs Rybelsus 7 mg with Ozempic 4 mg tablets, and 14 mg with 9 mg. It says not to switch between them in the first 30 days.
If a dose is missed
Skip the missed tablet and take the next one the following day.
Log your Rybelsus doses in Gliplog
- Pick a strength from Rybelsus’s label in a tap
- Log each dose and see when the next one is due
- Free, private, and offline. Nothing leaves your device.
Questions about Rybelsus dosing
What is the starting dose of Rybelsus?
The label starts Rybelsus at 3 mg once a day for 30 days. It notes that 3 mg doesn’t lower blood sugar: it is there to start. On day 31 the dose goes up to 7 mg.
When can Rybelsus go up to 14 mg?
From day 61, if more blood sugar control is needed, according to the label. Your prescriber decides.
Is Rybelsus the same as Ozempic tablets?
Both are semaglutide tablets on one label, but in different strengths that the label says are not swapped milligram for milligram.
What if I miss a Rybelsus tablet?
The label says to skip it and take the next tablet the following day.
Other dosing schedules
Source: RYBELSUS and OZEMPIC (semaglutide) tablets US prescribing information, section 2 (revised 1/2026). Not medical advice; Gliplog never recommends a dose. Ask your prescriber or pharmacist.